[HTML][HTML] Hyperactivation of mammalian target of rapamycin (mTOR) signaling by a gain-of-function mutant of the Rheb GTPase
L Yan, GM Findlay, R Jones, J Procter, Y Cao… - Journal of biological …, 2006 - ASBMB
Gain-of-function mutants of Ras and Rho family small GTPases have proven to be important
tools in analyzing signaling downstream of these small GTPases. The Ras-related GTPase
Rheb has emerged as a key player downstream of TSC1–2 in activating signaling to
mammalian target of rapamycin (mTOR) effectors of cell growth such as S6K and 4E-BP1.
The TSC1–2 tumor suppressor complex has been shown to act as a RhebGAP, converting
Rheb from a GTP-bound to a GDP-bound form. Here we report the identification of a mutant …
tools in analyzing signaling downstream of these small GTPases. The Ras-related GTPase
Rheb has emerged as a key player downstream of TSC1–2 in activating signaling to
mammalian target of rapamycin (mTOR) effectors of cell growth such as S6K and 4E-BP1.
The TSC1–2 tumor suppressor complex has been shown to act as a RhebGAP, converting
Rheb from a GTP-bound to a GDP-bound form. Here we report the identification of a mutant …