[HTML][HTML] Manipulation of EphB2 regulatory motifs and SH2 binding sites switches MAPK signaling and biological activity
Signaling by the Eph family of receptor tyrosine kinases (RTKs) is complex, because they
can interact with a variety of intracellular targets, and can potentially induce distinct
responses in different cell types. In NG108 neuronal cells, activated EphB2 recruits
p120RasGAP, in a fashion that is associated with down-regulation of the Ras-Erk mitogen-
activated kinase (MAPK) pathway and neurite retraction. To pursue the role of the Ras-
MAPK pathway in EphB2-mediated growth cone collapse, and to explore the biochemical …
can interact with a variety of intracellular targets, and can potentially induce distinct
responses in different cell types. In NG108 neuronal cells, activated EphB2 recruits
p120RasGAP, in a fashion that is associated with down-regulation of the Ras-Erk mitogen-
activated kinase (MAPK) pathway and neurite retraction. To pursue the role of the Ras-
MAPK pathway in EphB2-mediated growth cone collapse, and to explore the biochemical …
