[HTML][HTML] Fibronectin and β-catenin act in a regulatory loop in dermal fibroblasts to modulate cutaneous healing
KA Bielefeld, S Amini-Nik, H Whetstone, R Poon… - Journal of Biological …, 2011 - ASBMB
β-Catenin is an important regulator of dermal fibroblasts during cutaneous wound repair.
However, the factors that modulate β-catenin activity in this process are not completely
understood. We investigated the role of the extracellular matrix in regulating β-catenin and
found an increase in β-catenin-mediated Tcf-dependent transcriptional activity in fibroblasts
exposed to various extracellular matrix components. This occurs through an integrin-
mediated GSK3β-dependent pathway. The physiologic role of this mechanism was …
However, the factors that modulate β-catenin activity in this process are not completely
understood. We investigated the role of the extracellular matrix in regulating β-catenin and
found an increase in β-catenin-mediated Tcf-dependent transcriptional activity in fibroblasts
exposed to various extracellular matrix components. This occurs through an integrin-
mediated GSK3β-dependent pathway. The physiologic role of this mechanism was …