Endothelin-1 participation in overt and inflammatory pain
SH Ferreira, M Romitelli… - Journal of cardiovascular …, 1989 - journals.lww.com
SH Ferreira, M Romitelli, G De Nucci
Journal of cardiovascular pharmacology, 1989•journals.lww.comEndothelin-1 (ET-1) induced hyperalgesia in rats, abdominal constrictions in mice,
incapacitation in dogs, and, when injected intradermally into humans, caused wheal and
flare responses, which were accompanied by itching. The ET-1 induced constrictions in mice
were prevented by indomethacin. In contrast, indomethacin had no effect on the
hyperalgesic responses in the rat. These results indicate that ET-1 may play a role in
modulating pain.
incapacitation in dogs, and, when injected intradermally into humans, caused wheal and
flare responses, which were accompanied by itching. The ET-1 induced constrictions in mice
were prevented by indomethacin. In contrast, indomethacin had no effect on the
hyperalgesic responses in the rat. These results indicate that ET-1 may play a role in
modulating pain.
Abstract
Endothelin-1 (ET-1) induced hyperalgesia in rats, abdominal constrictions in mice, incapacitation in dogs, and, when injected intradermally into humans, caused wheal and flare responses, which were accompanied by itching. The ET-1 induced constrictions in mice were prevented by indomethacin. In contrast, indomethacin had no effect on the hyperalgesic responses in the rat. These results indicate that ET-1 may play a role in modulating pain.
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