Hypoxia and hypoxia mimetics inhibit TNF-dependent VCAM1 induction in the 5A32 endothelial cell line via a hypoxia inducible factor dependent mechanism
TV Cartee, KJ White, M Newton-West… - Journal of dermatological …, 2012 - Elsevier
BACKGROUND: We previously reported that iron chelators inhibit TNFα-mediated induction
of VCAM-1 in human dermal microvascular endothelial cells. We hypothesized that iron
chelators mediate inhibition of VCAM-1 via inhibition of iron-dependent enzymes such as
those involved with oxygen sensing and that similar inhibition may be observed with agents
which simulate hypoxia. OBJECTIVE: We proposed to examine whether non-metal binding
hypoxia mimetics inhibit TNFα-mediated VCAM-1 induction and define the mechanisms by …
of VCAM-1 in human dermal microvascular endothelial cells. We hypothesized that iron
chelators mediate inhibition of VCAM-1 via inhibition of iron-dependent enzymes such as
those involved with oxygen sensing and that similar inhibition may be observed with agents
which simulate hypoxia. OBJECTIVE: We proposed to examine whether non-metal binding
hypoxia mimetics inhibit TNFα-mediated VCAM-1 induction and define the mechanisms by …