[HTML][HTML] The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and …

M Korpal, ES Lee, G Hu, Y Kang - Journal of Biological Chemistry, 2008 - ASBMB
MicroRNAs are small non-coding RNA molecules that can regulate gene expression by
interacting with multiple mRNAs and inducing either translation suppression or degradation
of mRNA. Recently, several miRNAs were identified as either promoters or suppressors of
metastasis. However, it is unclear in which step (s) of the multistep metastatic cascade these
miRNAs play a defined functional role. To study the functional importance of miRNAs in
epithelial-mesenchymal transition (EMT), a process thought to initiate metastasis by …