[HTML][HTML] Ex vivo expansion of human hematopoietic stem cells by a small-molecule agonist of c-MPL
T Nishino, K Miyaji, N Ishiwata, K Arai, M Yui… - Experimental …, 2009 - Elsevier
OBJECTIVE: The signaling by thrombopoietin (TPO) via its receptor, c-MPL, plays a crucial
role in the maintenance of hematopoietic stem cells (HSCs). Small-molecule c-MPL agonists
have recently been shown to be beneficial in the treatment of thrombocytopenia. However,
their effects on HSCs have not yet been explored. In this study, we evaluated the effects of
NR-101, a novel small-molecule c-MPL agonist, on the ex vivo expansion of human cord
blood (hCB) HSCs. MATERIALS AND METHODS: hCB CD34+ or CD34+ CD38 …
role in the maintenance of hematopoietic stem cells (HSCs). Small-molecule c-MPL agonists
have recently been shown to be beneficial in the treatment of thrombocytopenia. However,
their effects on HSCs have not yet been explored. In this study, we evaluated the effects of
NR-101, a novel small-molecule c-MPL agonist, on the ex vivo expansion of human cord
blood (hCB) HSCs. MATERIALS AND METHODS: hCB CD34+ or CD34+ CD38 …