[HTML][HTML] Differential roles of Epac in regulating cell death in neuronal and myocardial cells
S Suzuki, U Yokoyama, T Abe, H Kiyonari… - Journal of biological …, 2010 - ASBMB
Cell survival and death play critical roles in tissues composed of post-mitotic cells. Cyclic
AMP (cAMP) has been known to exert a distinct effect on cell susceptibility to apoptosis,
protecting neuronal cells and deteriorating myocardial cells. These effects are primarily
studied using protein kinase A activation. In this study we show the differential roles of Epac,
an exchange protein activated by cAMP and a new effector molecule of cAMP signaling, in
regulating apoptosis in these cell types. Both stimulation of Epac by 8-p-methoxyphenylthon …
AMP (cAMP) has been known to exert a distinct effect on cell susceptibility to apoptosis,
protecting neuronal cells and deteriorating myocardial cells. These effects are primarily
studied using protein kinase A activation. In this study we show the differential roles of Epac,
an exchange protein activated by cAMP and a new effector molecule of cAMP signaling, in
regulating apoptosis in these cell types. Both stimulation of Epac by 8-p-methoxyphenylthon …