[HTML][HTML] Rescue of contractile parameters and myocyte hypertrophy in calsequestrin overexpressing myocardium by phospholamban ablation
Y Sato, H Kiriazis, A Yatani, AG Schmidt, H Hahn… - Journal of Biological …, 2001 - ASBMB
Cardiac-specific overexpression of murine cardiac calsequestrin results in depressed
cardiac contractile parameters, low Ca 2+-induced Ca 2+ release from sarcoplasmic
reticulum (SR) and cardiac hypertrophy in transgenic mice. To test the hypothesis that
inhibition of phospholamban activity may rescue some of these phenotypic alterations, the
calsequestrin overexpressing mice were cross-bred with phospholamban-knockout mice.
Phospholamban ablation in calsequestrin overexpressing mice led to reversal of the …
cardiac contractile parameters, low Ca 2+-induced Ca 2+ release from sarcoplasmic
reticulum (SR) and cardiac hypertrophy in transgenic mice. To test the hypothesis that
inhibition of phospholamban activity may rescue some of these phenotypic alterations, the
calsequestrin overexpressing mice were cross-bred with phospholamban-knockout mice.
Phospholamban ablation in calsequestrin overexpressing mice led to reversal of the …