Mitochondria and apoptosis

DR Green, JC Reed - science, 1998 - science.org
DR Green, JC Reed
science, 1998science.org
REVIEW A variety of key events in apoptosis focus on mitochondria, including the release of
caspase activators (such as cytochrome c), changes in electron transport, loss of
mitochondrial transmembrane potential, altered cellular oxidation-reduction, and
participation of pro-and antiapoptotic Bcl-2 family proteins. The different signals that
converge on mitochondria to trigger or inhibit these events and their downstream effects
delineate several major pathways in physiological cell death.
REVIEW
A variety of key events in apoptosis focus on mitochondria, including the release of caspase activators (such as cytochrome c), changes in electron transport, loss of mitochondrial transmembrane potential, altered cellular oxidation-reduction, and participation of pro- and antiapoptotic Bcl-2 family proteins. The different signals that converge on mitochondria to trigger or inhibit these events and their downstream effects delineate several major pathways in physiological cell death.
AAAS