Influence on blood pressure of renal isografts between spontaneously hypertensive and normotensive rats, utilizing the F1 hybrids
K Kawabe, TX WATANABE, K SHIONO… - Japanese heart …, 1978 - jstage.jst.go.jp
K Kawabe, TX WATANABE, K SHIONO, H SOKABE
Japanese heart journal, 1978•jstage.jst.go.jpSUMMARY The F1 hybrids (F1) of spontaneously hypertensive rats (SHR) and Wistar rats
(W), whose kidneys were transplanted from SHR at the age of 10 weeks and 20 weeks,
showed significant elevation of blood pressure (BP) for 11 weeks after the transplantation. In
F1 with W or F1 kidneys BP was decreased near to the normal level. F1 whose kidneys were
transplanted from SHR or W showed low renin activity both in plasma and the kidney. It is
suggested that BP of SHR is probably determined by the renal pro-hypertensive factor (s) …
(W), whose kidneys were transplanted from SHR at the age of 10 weeks and 20 weeks,
showed significant elevation of blood pressure (BP) for 11 weeks after the transplantation. In
F1 with W or F1 kidneys BP was decreased near to the normal level. F1 whose kidneys were
transplanted from SHR or W showed low renin activity both in plasma and the kidney. It is
suggested that BP of SHR is probably determined by the renal pro-hypertensive factor (s) …
SUMMARY The F1 hybrids (F1) of spontaneously hypertensive rats (SHR) and Wistar rats (W), whose kidneys were transplanted from SHR at the age of 10 weeks and 20 weeks, showed significant elevation of blood pressure (BP) for 11 weeks after the transplantation. In F1 with W or F1 kidneys
BP was decreased near to the normal level. F1 whose kidneys were transplanted from SHR or W showed low renin activity both in plasma and the kidney. It is suggested that BP of SHR is probably determined by the renal pro-hypertensive factor (s) other than renin influencing on sympathetic nerves through central nervous systems.
jstage.jst.go.jp