IL-2/anti-IL-2 complex attenuates renal ischemia-reperfusion injury through expansion of regulatory T cells
MG Kim, TY Koo, JJ Yan, E Lee, KH Han… - Journal of the …, 2013 - journals.lww.com
Regulatory T cells (Tregs) can suppress immunologic damage in renal ischemia-reperfusion
injury (IRI), but the isolation and ex vivo expansion of these cells for clinical application
remains challenging. Here, we investigated whether the IL-2/anti-IL-2 complex (IL-2C), a
mediator of Treg expansion, can attenuate renal IRI in mice. IL-2C administered before
bilateral renal IRI induced Treg expansion in both spleen and kidney, improved renal
function, and attenuated histologic renal injury and apoptosis after IRI. Furthermore, IL-2C …
injury (IRI), but the isolation and ex vivo expansion of these cells for clinical application
remains challenging. Here, we investigated whether the IL-2/anti-IL-2 complex (IL-2C), a
mediator of Treg expansion, can attenuate renal IRI in mice. IL-2C administered before
bilateral renal IRI induced Treg expansion in both spleen and kidney, improved renal
function, and attenuated histologic renal injury and apoptosis after IRI. Furthermore, IL-2C …