[HTML][HTML] Chronic airway infection/inflammation induces a Ca2+ i-dependent hyperinflammatory response in human cystic fibrosis airway epithelia
CMP Ribeiro, AM Paradiso, U Schwab… - Journal of Biological …, 2005 - ASBMB
Hyperinflammatory responses to infection have been postulated as a component of cystic
fibrosis (CF) lung disease. Studies have linked intracellular calcium (Ca 2+ i) mobilization
with inflammatory responses in several systems. We have reported that the pro-inflammatory
mediator bradykinin (BK) promotes larger Ca 2+ i signals in CF compared with normal
bronchial epithelia, a response that reflects endoplasmic reticulum (ER)/Ca 2+ store
expansion induced by chronic luminal airway infection/inflammation. The present study …
fibrosis (CF) lung disease. Studies have linked intracellular calcium (Ca 2+ i) mobilization
with inflammatory responses in several systems. We have reported that the pro-inflammatory
mediator bradykinin (BK) promotes larger Ca 2+ i signals in CF compared with normal
bronchial epithelia, a response that reflects endoplasmic reticulum (ER)/Ca 2+ store
expansion induced by chronic luminal airway infection/inflammation. The present study …