Expression of the anaphylatoxin C5a receptor in the oligodendrocyte lineage
Brain research, 2001•Elsevier
Expression of the C5a receptor in the central nervous system has been demonstrated on
microglia, astrocytes and neurons. In the present study, we demonstrate C5aR expression in
vitro by rat and murine O2-A progenitor cells and oligodendrocytes. We also observed that in
vitro differentiation of O2-A progenitors into mature oligodendrocytes is accompanied by
down-regulation of C5aR mRNA expression. These results suggest that the C5aR may be a
marker for oligodendroglial differentiation and play a role in oligodendrocyte function.
microglia, astrocytes and neurons. In the present study, we demonstrate C5aR expression in
vitro by rat and murine O2-A progenitor cells and oligodendrocytes. We also observed that in
vitro differentiation of O2-A progenitors into mature oligodendrocytes is accompanied by
down-regulation of C5aR mRNA expression. These results suggest that the C5aR may be a
marker for oligodendroglial differentiation and play a role in oligodendrocyte function.
Expression of the C5a receptor in the central nervous system has been demonstrated on microglia, astrocytes and neurons. In the present study, we demonstrate C5aR expression in vitro by rat and murine O2-A progenitor cells and oligodendrocytes. We also observed that in vitro differentiation of O2-A progenitors into mature oligodendrocytes is accompanied by down-regulation of C5aR mRNA expression. These results suggest that the C5aR may be a marker for oligodendroglial differentiation and play a role in oligodendrocyte function.
Elsevier