Lipotoxicity: when tissues overeat
JE Schaffer - Current opinion in lipidology, 2003 - journals.lww.com
Current opinion in lipidology, 2003•journals.lww.com
Recent studies provide clues regarding the cellular mechanisms that determine whether
excess lipid accumulation is well tolerated or cytotoxic. Critical in this process are
physiologic mechanisms for directing excess free fatty acids to specific tissues as well as
cellular mechanisms for channeling excess fatty acid to particular metabolic fates. Insight
into these mechanisms may contribute to the development of more effective therapies for
common human disorders in which lipotoxicity contributes to pathogenesis.
excess lipid accumulation is well tolerated or cytotoxic. Critical in this process are
physiologic mechanisms for directing excess free fatty acids to specific tissues as well as
cellular mechanisms for channeling excess fatty acid to particular metabolic fates. Insight
into these mechanisms may contribute to the development of more effective therapies for
common human disorders in which lipotoxicity contributes to pathogenesis.
Summary
Recent studies provide clues regarding the cellular mechanisms that determine whether excess lipid accumulation is well tolerated or cytotoxic. Critical in this process are physiologic mechanisms for directing excess free fatty acids to specific tissues as well as cellular mechanisms for channeling excess fatty acid to particular metabolic fates. Insight into these mechanisms may contribute to the development of more effective therapies for common human disorders in which lipotoxicity contributes to pathogenesis.
Lippincott Williams & Wilkins