Role of the cysteine protease cathepsin S in neuropathic hyperalgesia
J Barclay, AK Clark, P Ganju, C Gentry, S Patel… - Pain, 2007 - Elsevier
Using a gene expression analysis approach we found that the mRNA encoding the
lysosomal cysteine protease cathepsin S (CatS) was up-regulated in rat dorsal root ganglia
(DRG) following peripheral nerve injury. CatS protein was expressed in infiltrating
macrophages in DRG and near the site of injury. At both sites CatS expression progressively
increased from day 3 to day 14 after injury. In naïve rats, intraplantar injection of activated rat
recombinant (rr) CatS (0.3, 1 μg/rat) induced a mechanical hyperalgesia that developed …
lysosomal cysteine protease cathepsin S (CatS) was up-regulated in rat dorsal root ganglia
(DRG) following peripheral nerve injury. CatS protein was expressed in infiltrating
macrophages in DRG and near the site of injury. At both sites CatS expression progressively
increased from day 3 to day 14 after injury. In naïve rats, intraplantar injection of activated rat
recombinant (rr) CatS (0.3, 1 μg/rat) induced a mechanical hyperalgesia that developed …