[HTML][HTML] Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia: reversal by cholic acid feeding

JJ Repa, EG Lund, JD Horton, E Leitersdorf… - Journal of Biological …, 2000 - ASBMB
Sterol 27-hydroxylase (CYP27) participates in the conversion of cholesterol to bile acids. We
examined lipid metabolism in mice lacking the Cyp27 gene. On normal rodent chow,
Cyp27−/− mice have 40% larger livers, 45% larger adrenals, 2-fold higher hepatic and
plasma triacylglycerol concentrations, a 70% higher rate of hepatic fatty acid synthesis, and
a 70% increase in the ratio of oleic to stearic acid in the liverversus Cyp27+/+ controls.
InCyp27−/− mice, cholesterol 7α-hydroxylase activity is increased 5-fold, but bile acid …