[HTML][HTML] Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor
M Ananthanarayanan, N Balasubramanian… - Journal of Biological …, 2001 - ASBMB
The bile salt excretory pump (BSEP, ABCb11) is critical for ATP-dependent transport of bile
acids across the hepatocyte canalicular membrane and for generation of bile acid-
dependent bile secretion. Recent studies have demonstrated that the expression of this
transporter is sensitive to the flux of bile acids through the hepatocyte, possibly at the level of
transcription of the BSEP gene. To determine the mechanisms underlying the regulation of
BSEP by bile acids, the promoter of the BSEP gene was cloned. The sequence of the …
acids across the hepatocyte canalicular membrane and for generation of bile acid-
dependent bile secretion. Recent studies have demonstrated that the expression of this
transporter is sensitive to the flux of bile acids through the hepatocyte, possibly at the level of
transcription of the BSEP gene. To determine the mechanisms underlying the regulation of
BSEP by bile acids, the promoter of the BSEP gene was cloned. The sequence of the …