The constitutive androstane receptor (CAR) is a xenosensing nuclear receptor and regulator
of cytochrome P450s (CYPs). However, the role of CAR as a basal regulator of CYP
expression nor its role in sexually dimorphic responses have been thoroughly studied. We
investigated basal regulation and sexually dimorphic regulation and induction by the potent
CAR activator TCPOBOP and the moderate CAR activator Nonylphenol (NP). NP is an
environmental estrogen and one of the most commonly found environmental toxicants in …