[HTML][HTML] Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts
Leptin administration to obese C57BL/6J (ob/ob) mice results in weight loss by reducing
body fat. Because adipose tissue is an important storage depot for cholesterol, we explored
evidence that leptin-induced weight loss inob/ob mice was accompanied by transport of
cholesterol to the liver and its elimination via bile. Consistent with mobilization of stored
cholesterol, cholesterol concentrations in adipose tissue remained unchanged during
weight loss. Plasma cholesterol levels fell sharply, and microscopic analyses of gallbladder …
body fat. Because adipose tissue is an important storage depot for cholesterol, we explored
evidence that leptin-induced weight loss inob/ob mice was accompanied by transport of
cholesterol to the liver and its elimination via bile. Consistent with mobilization of stored
cholesterol, cholesterol concentrations in adipose tissue remained unchanged during
weight loss. Plasma cholesterol levels fell sharply, and microscopic analyses of gallbladder …