Intracerebroventricular leptin regulates hepatic cholesterol metabolism
S VanPATTEN, GB Karkanias, L Rossetti… - Biochemical …, 2004 - portlandpress.com
S VanPATTEN, GB Karkanias, L Rossetti, DE Cohen
Biochemical Journal, 2004•portlandpress.comTo elucidate the control of hepatic cholesterol metabolism by leptin, rats were administered
IV (intravenous) leptin, ICV (intracerebroventricular) leptin or saline. A single low dose of ICV
leptin was as effective as a continuous IV infusion of highdose leptin at decreasing the
activities of 3-hydroxy-3-methylglutaryl-CoA reductase and cholesterol 7α-hydroxylase.
These results indicate that the hepatic response to leptin is transduced via the central
nervous system.
IV (intravenous) leptin, ICV (intracerebroventricular) leptin or saline. A single low dose of ICV
leptin was as effective as a continuous IV infusion of highdose leptin at decreasing the
activities of 3-hydroxy-3-methylglutaryl-CoA reductase and cholesterol 7α-hydroxylase.
These results indicate that the hepatic response to leptin is transduced via the central
nervous system.
To elucidate the control of hepatic cholesterol metabolism by leptin, rats were administered IV (intravenous) leptin, ICV (intracerebroventricular) leptin or saline. A single low dose of ICV leptin was as effective as a continuous IV infusion of highdose leptin at decreasing the activities of 3-hydroxy-3-methylglutaryl-CoA reductase and cholesterol 7α-hydroxylase. These results indicate that the hepatic response to leptin is transduced via the central nervous system.
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