[HTML][HTML] A mutated form of steroidogenic factor 1 (SF-1 G35E) that causes sex reversal in humans fails to synergize with transcription factor GATA-4
JJ Tremblay, RS Viger - Journal of Biological Chemistry, 2003 - ASBMB
Steroidogenic factor 1 (SF-1) is a transcription factor belonging to the nuclear receptor
superfamily. SF-1 regulates the expression of many genes involved in reproduction,
steroidogenesis, and sexual differentiation. An important SF-1 target for male sexual
differentiation is the gene encoding the Müllerian-inhibiting substance hormone that
induces regression of the Müllerian ducts in the developing male embryo. Not long ago, a
mutation (G35E) in the human SF-1 gene was identified as the cause of sex reversal and …
superfamily. SF-1 regulates the expression of many genes involved in reproduction,
steroidogenesis, and sexual differentiation. An important SF-1 target for male sexual
differentiation is the gene encoding the Müllerian-inhibiting substance hormone that
induces regression of the Müllerian ducts in the developing male embryo. Not long ago, a
mutation (G35E) in the human SF-1 gene was identified as the cause of sex reversal and …