Autophagy: from phenomenology to molecular understanding in less than a decade
DJ Klionsky - Nature reviews Molecular cell biology, 2007 - nature.com
Nature reviews Molecular cell biology, 2007•nature.com
In 2000, it was suggested to me that “Autophagy will be the wave of the future; it will become
the new apoptosis.” Few people would have agreed at the time, but this statement turned out
to be prophetic, and this process of'self-eating'rapidly exploded as a research field, as
scientists discovered connections to cancer, neurodegeneration and even lifespan
extension. Amazingly, the molecular breakthroughs in autophagy have taken place during
only the past decade.
the new apoptosis.” Few people would have agreed at the time, but this statement turned out
to be prophetic, and this process of'self-eating'rapidly exploded as a research field, as
scientists discovered connections to cancer, neurodegeneration and even lifespan
extension. Amazingly, the molecular breakthroughs in autophagy have taken place during
only the past decade.
Abstract
In 2000, it was suggested to me that “Autophagy will be the wave of the future; it will become the new apoptosis.” Few people would have agreed at the time, but this statement turned out to be prophetic, and this process of 'self-eating' rapidly exploded as a research field, as scientists discovered connections to cancer, neurodegeneration and even lifespan extension. Amazingly, the molecular breakthroughs in autophagy have taken place during only the past decade.
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