[HTML][HTML] Activity and regulation of the centrosome-associated proteasome
RP Fabunmi, WC Wigley, PJ Thomas… - Journal of biological …, 2000 - ASBMB
Regulated proteolysis is important for maintaining appropriate cellular levels of many
proteins. The bulk of intracellular protein degradation is catalyzed by the proteasome.
Recently, the centrosome was identified as a novel site for concentration of the proteasome
and associated regulatory proteins (Wigley, WC, Fabunmi, RP, Lee, MG, Marino, CR,
Muallem, S., DeMartino, GN, and Thomas, PJ (1999) J. Cell Biol. 145, 481–490). Here we
provide evidence that centrosomes contain the active 26 S proteasome that degrades …
proteins. The bulk of intracellular protein degradation is catalyzed by the proteasome.
Recently, the centrosome was identified as a novel site for concentration of the proteasome
and associated regulatory proteins (Wigley, WC, Fabunmi, RP, Lee, MG, Marino, CR,
Muallem, S., DeMartino, GN, and Thomas, PJ (1999) J. Cell Biol. 145, 481–490). Here we
provide evidence that centrosomes contain the active 26 S proteasome that degrades …