[HTML][HTML] Hooked! Modeling human disease in zebrafish

C Santoriello, LI Zon - The Journal of clinical investigation, 2012 - Am Soc Clin Investig
The Journal of clinical investigation, 2012Am Soc Clin Investig
Zebrafish have been widely used as a model system for studying developmental processes,
but in the last decade, they have also emerged as a valuable system for modeling human
disease. The development and function of zebrafish organs are strikingly similar to those of
humans, and the ease of creating mutant or transgenic fish has facilitated the generation of
disease models. Here, we highlight the use of zebrafish for defining disease pathways and
for discovering new therapies.
Zebrafish have been widely used as a model system for studying developmental processes, but in the last decade, they have also emerged as a valuable system for modeling human disease. The development and function of zebrafish organs are strikingly similar to those of humans, and the ease of creating mutant or transgenic fish has facilitated the generation of disease models. Here, we highlight the use of zebrafish for defining disease pathways and for discovering new therapies.
The Journal of Clinical Investigation