4-1BB promotes the survival of CD8+ T lymphocytes by increasing expression of Bcl-xL and Bfl-1
HW Lee, SJ Park, BK Choi, HH Kim… - The Journal of …, 2002 - journals.aai.org
HW Lee, SJ Park, BK Choi, HH Kim, KO Nam, BS Kwon
The Journal of Immunology, 2002•journals.aai.org1BB, a T cell costimulatory receptor, prolongs CD8+ T cell survival. In these studies, 4-1BB
stimulation was shown to increase expression of the antiapoptotic genes bcl-x L and bfl-1
via 4-1BB-mediated NF-κB activation. This signaling pathway was specifically inhibited by
PDTC and was different from the pathways that enhanced CD8+ T cell proliferation. The
results suggest a role for the antiapoptotic activities of Bcl-x L and Bfl-1 proteins in 4-1BB-
mediated CD8+ T cell survival in vivo.
stimulation was shown to increase expression of the antiapoptotic genes bcl-x L and bfl-1
via 4-1BB-mediated NF-κB activation. This signaling pathway was specifically inhibited by
PDTC and was different from the pathways that enhanced CD8+ T cell proliferation. The
results suggest a role for the antiapoptotic activities of Bcl-x L and Bfl-1 proteins in 4-1BB-
mediated CD8+ T cell survival in vivo.
Abstract
4-1BB, a T cell costimulatory receptor, prolongs CD8+ T cell survival. In these studies, 4-1BB stimulation was shown to increase expression of the antiapoptotic genes bcl-x L and bfl-1 via 4-1BB-mediated NF-κB activation. This signaling pathway was specifically inhibited by PDTC and was different from the pathways that enhanced CD8+ T cell proliferation. The results suggest a role for the antiapoptotic activities of Bcl-x L and Bfl-1 proteins in 4-1BB-mediated CD8+ T cell survival in vivo.
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