A Wnt-fall for gene regulation: repression
NP Hoverter, ML Waterman - Science signaling, 2008 - science.org
NP Hoverter, ML Waterman
Science signaling, 2008•science.orgA major endpoint of the canonical Wnt signaling pathway is a change in the transcription of
target genes. The transcription factors lymphoid enhancer factor (LEF) and T cell factor
(TCF) serve as the main gatekeepers of these changes by selecting genes to be targeted by
the transcriptional coregulator β-catenin and by defining how target gene expression will be
altered. Most research has focused on LEF/TCF: β-catenin–mediated activation of
transcription, but there have been some reports that suggest that this complex also directly …
target genes. The transcription factors lymphoid enhancer factor (LEF) and T cell factor
(TCF) serve as the main gatekeepers of these changes by selecting genes to be targeted by
the transcriptional coregulator β-catenin and by defining how target gene expression will be
altered. Most research has focused on LEF/TCF: β-catenin–mediated activation of
transcription, but there have been some reports that suggest that this complex also directly …
A major endpoint of the canonical Wnt signaling pathway is a change in the transcription of target genes. The transcription factors lymphoid enhancer factor (LEF) and T cell factor (TCF) serve as the main gatekeepers of these changes by selecting genes to be targeted by the transcriptional coregulator β-catenin and by defining how target gene expression will be altered. Most research has focused on LEF/TCF:β-catenin–mediated activation of transcription, but there have been some reports that suggest that this complex also directly represses transcription. A recent study uncovered a new mode of repression of Wnt target genes in which recognition of a novel DNA element by TCF specifies that β-catenin acts as a transcriptional repressor.
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