Trichuris suis ova: testing a helminth-based therapy as an extension of the hygiene hypothesis
MH Jouvin, JP Kinet - Journal of allergy and clinical immunology, 2012 - Elsevier
The hygiene hypothesis, which was put forward more than 20 years ago by Strachan,
proposes that the recent increase in allergic and autoimmune diseases is due to increasing
hygiene standards. Since then, numerous epidemiologic and animal studies have provided
support for this hypothesis and showed that certain microorganisms, helminths in particular,
have immunomodulatory effects. More recently, studies have led to the identification of some
of the mechanisms underlying these immunomodulatory effects. Substances, or crude …
proposes that the recent increase in allergic and autoimmune diseases is due to increasing
hygiene standards. Since then, numerous epidemiologic and animal studies have provided
support for this hypothesis and showed that certain microorganisms, helminths in particular,
have immunomodulatory effects. More recently, studies have led to the identification of some
of the mechanisms underlying these immunomodulatory effects. Substances, or crude …