A general strategy for the generation of hypoallergenic molecules for the immunotherapy of fish allergy
I Swoboda, N Balic, C Klug, M Focke… - Journal of allergy and …, 2013 - jacionline.org
To the Editor: Surveys in the United States and Europe show that up to 0.5% of the
population suffers from fish allergy, 1, 2 which is a frequent cause of severe and life-
threatening anaphylactic reactions. Parvalbumin, a small calcium-binding protein, which is
extremely resistant to heat and digestion, represents the major fish allergen. Because of the
high degree of sequence homologies and cross-reactivities between parvalbumins from
different fish species, consumption of various fish species leads to clinical symptoms in fish …
population suffers from fish allergy, 1, 2 which is a frequent cause of severe and life-
threatening anaphylactic reactions. Parvalbumin, a small calcium-binding protein, which is
extremely resistant to heat and digestion, represents the major fish allergen. Because of the
high degree of sequence homologies and cross-reactivities between parvalbumins from
different fish species, consumption of various fish species leads to clinical symptoms in fish …