[HTML][HTML] Norepinephrine induces vascular endothelial growth factor gene expression in brown adipocytes through a β-adrenoreceptor/cAMP/protein kinase A pathway …
JM Fredriksson, JM Lindquist, GE Bronnikov… - Journal of Biological …, 2000 - ASBMB
To identify the signaling pathway that mediates the adrenergic stimulation of the expression
of the gene for vascular endothelial growth factor (VEGF) during physiologically induced
angiogenesis, we examined mouse brown adipocytes in primary culture. The endogenous
adrenergic neurotransmitter norepinephrine (NE) induced VEGF expression 3-fold, in a
dose-and time-dependent manner (EC 50≈ 90 nm). Also, the hypoxia-mimicking agent
cobalt, as well as serum and phorbol ester, induced VEGF expression, but the effect of NE …
of the gene for vascular endothelial growth factor (VEGF) during physiologically induced
angiogenesis, we examined mouse brown adipocytes in primary culture. The endogenous
adrenergic neurotransmitter norepinephrine (NE) induced VEGF expression 3-fold, in a
dose-and time-dependent manner (EC 50≈ 90 nm). Also, the hypoxia-mimicking agent
cobalt, as well as serum and phorbol ester, induced VEGF expression, but the effect of NE …