IL-12–and IL-23–induced T helper cell subsets: birds of the same feather flock together
E Bettelli, VK Kuchroo - The Journal of experimental medicine, 2005 - rupress.org
E Bettelli, VK Kuchroo
The Journal of experimental medicine, 2005•rupress.orgTraditionally, CD4+ T cells have been separated into two different subsets named T helper
(Th) 1 and Th2. A new IL-23–driven subset of Th cells called ThIL-17 has now been
described. The data suggest that IL-23 plays an important role in the differentiation of
autoreactive pathogenic T cells. Whether these IL-23–induced ThIL-17 cells are a unique
subset or are related to other Th subsets is discussed.
(Th) 1 and Th2. A new IL-23–driven subset of Th cells called ThIL-17 has now been
described. The data suggest that IL-23 plays an important role in the differentiation of
autoreactive pathogenic T cells. Whether these IL-23–induced ThIL-17 cells are a unique
subset or are related to other Th subsets is discussed.
Traditionally, CD4+ T cells have been separated into two different subsets named T helper (Th)1 and Th2. A new IL-23–driven subset of Th cells called ThIL-17 has now been described. The data suggest that IL-23 plays an important role in the differentiation of autoreactive pathogenic T cells. Whether these IL-23–induced ThIL-17 cells are a unique subset or are related to other Th subsets is discussed.
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