[HTML][HTML] Transplant acceptance following anti-CD4 versus anti-CD40L therapy: evidence for differential maintenance of graft-reactive T cells
SC Wood, G Lu, BE Burrell, DK Bishop - American Journal of …, 2008 - Elsevier
Inductive therapy with anti-CD4 or anti-CD40L monoclonal antibodies (mAb) leads to long-
term allograft acceptance but the immune parameters responsible for graft maintenance are
not well understood. This study employed an adoptive transfer system in which cells from
mice bearing long-term cardiac allografts following inductive anti-CD4 or anti-CD40L
therapy were transferred into severe combined immunodeficiency (SCID) allograft
recipients. SCID recipients of cells from anti-CD4-treated mice (anti-CD4 cells) did not reject …
term allograft acceptance but the immune parameters responsible for graft maintenance are
not well understood. This study employed an adoptive transfer system in which cells from
mice bearing long-term cardiac allografts following inductive anti-CD4 or anti-CD40L
therapy were transferred into severe combined immunodeficiency (SCID) allograft
recipients. SCID recipients of cells from anti-CD4-treated mice (anti-CD4 cells) did not reject …