LKB1—a master tumour suppressor of the small intestine and beyond
LI Yoo, DC Chung, J Yuan - Nature Reviews Cancer, 2002 - nature.com
LI Yoo, DC Chung, J Yuan
Nature Reviews Cancer, 2002•nature.comPeutz–Jeghers syndrome (PJS) is a rare, inherited intestinal polyposis syndrome that is
associated with a significantly increased risk of several types of cancer—particularly those of
the gastrointestinal and reproductive systems. Most cases of PJS have been associated with
loss-of-function mutations in the ubiquitously expressed LKB1 gene, which encodes a
serine/threonine kinase. Recent studies have begun to illustrate the molecular mechanisms
by which LKB1 functions as an important new tumour suppressor.
associated with a significantly increased risk of several types of cancer—particularly those of
the gastrointestinal and reproductive systems. Most cases of PJS have been associated with
loss-of-function mutations in the ubiquitously expressed LKB1 gene, which encodes a
serine/threonine kinase. Recent studies have begun to illustrate the molecular mechanisms
by which LKB1 functions as an important new tumour suppressor.
Abstract
Peutz–Jeghers syndrome (PJS) is a rare, inherited intestinal polyposis syndrome that is associated with a significantly increased risk of several types of cancer — particularly those of the gastrointestinal and reproductive systems. Most cases of PJS have been associated with loss-of-function mutations in the ubiquitously expressed LKB1 gene, which encodes a serine/ threonine kinase. Recent studies have begun to illustrate the molecular mechanisms by which LKB1 functions as an important new tumour suppressor.
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