Backup pathways of NHEJ in cells of higher eukaryotes: cell cycle dependence
G Iliakis - Radiotherapy and Oncology, 2009 - Elsevier
DNA double-strand breaks (DSBs) induced by ionizing radiation (IR) in cells of higher
eukaryotes are predominantly repaired by a pathway of non-homologous end joining
(NHEJ) utilizing Ku, DNA-PKcs, DNA ligase IV, XRCC4 and XLF/Cernunnos (D-NHEJ) as
central components. Work carried out in our laboratory and elsewhere shows that when this
pathway is chemically or genetically compromised, cells do not shunt DSBs to homologous
recombination repair (HRR) but instead use another form of NHEJ operating as a backup (B …
eukaryotes are predominantly repaired by a pathway of non-homologous end joining
(NHEJ) utilizing Ku, DNA-PKcs, DNA ligase IV, XRCC4 and XLF/Cernunnos (D-NHEJ) as
central components. Work carried out in our laboratory and elsewhere shows that when this
pathway is chemically or genetically compromised, cells do not shunt DSBs to homologous
recombination repair (HRR) but instead use another form of NHEJ operating as a backup (B …