[PDF][PDF] Binding reactions: epigenetic switches, signal transduction and cancer
M Ptashne - Current Biology, 2009 - cell.com
M Ptashne
Current Biology, 2009•cell.comBinding reactions: epigenetic switches, signal transduction and cancer Page 1 Current Biology
Vol 19 No 6 R234 the mechanisms by which buds arise and differentiate. Recent work has
shown that in most species each reiterated sequence — rather than each zooid — arises as a
single bud within the growth zone and then gives rise to multiple zooids through subdivision.
Siphonophores also have complex symmetry properties that deviate from the simple radial
symmetry usually associated with cnidarians. The colonies can even be directionally asymmetric …
Vol 19 No 6 R234 the mechanisms by which buds arise and differentiate. Recent work has
shown that in most species each reiterated sequence — rather than each zooid — arises as a
single bud within the growth zone and then gives rise to multiple zooids through subdivision.
Siphonophores also have complex symmetry properties that deviate from the simple radial
symmetry usually associated with cnidarians. The colonies can even be directionally asymmetric …
Summary
Simple binding interactions lie at the heart of disparate biological functions. Multiple negative and positive ‘add-ons', often with small individual effects, make elementary systems that work, work better. Cancer illustrates various of these fundamental processes gone awry.
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