[HTML][HTML] cAMP-responsive element modulator (CREM) α protein induces interleukin 17A expression and mediates epigenetic alterations at the interleukin-17A gene …
IL-17A is a proinflammatory cytokine that is produced by specialized T helper cells and
contributes to the development of several autoimmune diseases such as systemic lupus
erythematosus (SLE). Transcription factor cAMP-responsive element modulator (CREM) α
displays increased expression levels in T cells from SLE patients and has been described to
account for aberrant T cell function in SLE pathogenesis. In this report, we provide evidence
that CREMα physically binds to a cAMP-responsive element, CRE (− 111/− 104), within the …
contributes to the development of several autoimmune diseases such as systemic lupus
erythematosus (SLE). Transcription factor cAMP-responsive element modulator (CREM) α
displays increased expression levels in T cells from SLE patients and has been described to
account for aberrant T cell function in SLE pathogenesis. In this report, we provide evidence
that CREMα physically binds to a cAMP-responsive element, CRE (− 111/− 104), within the …