Integrin avidity regulation: are changes in affinity and conformation underemphasized?
CV Carman, TA Springer - Current opinion in cell biology, 2003 - Elsevier
Current opinion in cell biology, 2003•Elsevier
Integrins play critical roles in development, wound healing, immunity and cancer. Central to
their function is their unique ability to modulate dynamically their adhesiveness through both
affinity-and valency-based mechanisms. Recent advances have shed light on the structural
basis for affinity regulation and on the signaling mechanisms responsible for both affinity
and valency modes of regulation.
their function is their unique ability to modulate dynamically their adhesiveness through both
affinity-and valency-based mechanisms. Recent advances have shed light on the structural
basis for affinity regulation and on the signaling mechanisms responsible for both affinity
and valency modes of regulation.
Integrins play critical roles in development, wound healing, immunity and cancer. Central to their function is their unique ability to modulate dynamically their adhesiveness through both affinity- and valency-based mechanisms. Recent advances have shed light on the structural basis for affinity regulation and on the signaling mechanisms responsible for both affinity and valency modes of regulation.
Elsevier