Determinant spreading and tumor responses after peptide-based cancer immunotherapy

A Ribas, JM Timmerman, LH Butterfield… - Trends in …, 2003 - cell.com
A Ribas, JM Timmerman, LH Butterfield, JS Economou
Trends in immunology, 2003cell.com
Modern immunological assays are very sensitive for detection of antigen-specific T cells.
These assays are used to detect increased levels of T cells after peptide-based
immunotherapy for cancer in an attempt to describe surrogate endpoints correlated with anti-
tumor activity. Recent reports demonstrate that determinant spreading develops in a high
frequency of subjects with tumor regression responses after this type of immunotherapy and
could be valuable for trial monitoring and the design of more effective vaccines.
Abstract
Modern immunological assays are very sensitive for detection of antigen-specific T cells. These assays are used to detect increased levels of T cells after peptide-based immunotherapy for cancer in an attempt to describe surrogate endpoints correlated with anti-tumor activity. Recent reports demonstrate that determinant spreading develops in a high frequency of subjects with tumor regression responses after this type of immunotherapy and could be valuable for trial monitoring and the design of more effective vaccines.
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