Increased levels of SPARC (osteonectin) in human breast cancer tissues and its association with clinical outcomes
G Watkins, A Douglas-Jones, R Bryce… - … and essential fatty acids, 2005 - Elsevier
SPARC (secreted protein acidic and rich in cystein), also known as osteonectin and BM40,
is a 32kDa secreted glycoprotein that interacts with extracellular matrix (ECM) proteins to
promote adhesion of cells from the matrix, thereby inducing a biological state conducive to
cell migration. SPARC is also thought to play an important role in tissue remodelling,
angiogenesis, embryonic development and tumourigenesis. The current study set out to
examine both the transcript levels of SPARC and the presence of the molecule in breast …
is a 32kDa secreted glycoprotein that interacts with extracellular matrix (ECM) proteins to
promote adhesion of cells from the matrix, thereby inducing a biological state conducive to
cell migration. SPARC is also thought to play an important role in tissue remodelling,
angiogenesis, embryonic development and tumourigenesis. The current study set out to
examine both the transcript levels of SPARC and the presence of the molecule in breast …