Gene targeting and expression analysis of mouse Tem1/endosialin using a lacZ reporter
HP Huang, CL Hong, CY Kao, SW Lin, SR Lin… - Gene Expression …, 2011 - Elsevier
TEM1 (endosialin) expression is increased in the stroma and tumor vasculature of several
common human cancers. The exact physiological role of TEM1 is still unknown since Tem1-
deficient mice are viable and show only a lower rate of abdominal site-specific tumor
invasion in tumor transplantation experiments. Previous studies have reported Tem1
expression in mouse embryos and adults, but did not determine the timing or location of the
earliest expression, and did not examine all organ systems. Using the highly sensitive Bluo …
common human cancers. The exact physiological role of TEM1 is still unknown since Tem1-
deficient mice are viable and show only a lower rate of abdominal site-specific tumor
invasion in tumor transplantation experiments. Previous studies have reported Tem1
expression in mouse embryos and adults, but did not determine the timing or location of the
earliest expression, and did not examine all organ systems. Using the highly sensitive Bluo …