In dystrophic hamsters losartan affects control of ventilation and dopamine D1 receptor density
EH Schlenker - Respiratory physiology & neurobiology, 2010 - Elsevier
The BIO 14.6 hamster (DV), an animal model of limb-girdle muscular dystrophy, has
elevated angiotensin AT1 receptors that may affect ventilation. Moreover, AT1 receptors may
modulate expression of dopamine D1 receptors. We investigated if chronic treatment of BIO
14.6 hamsters (DL) with losartan, an AT1 receptor blocker, affects D1 receptor density in the
striatum and nucleus tractus solitarius (NTS) and normalizes ventilation during exposure to
air, hypoxia, following hypoxia, and hypercapnia, Ventilation was evaluated using …
elevated angiotensin AT1 receptors that may affect ventilation. Moreover, AT1 receptors may
modulate expression of dopamine D1 receptors. We investigated if chronic treatment of BIO
14.6 hamsters (DL) with losartan, an AT1 receptor blocker, affects D1 receptor density in the
striatum and nucleus tractus solitarius (NTS) and normalizes ventilation during exposure to
air, hypoxia, following hypoxia, and hypercapnia, Ventilation was evaluated using …