[CITATION][C] Generation and role of calcium signal in adrenal glomerulosa cells
A Spat, P Enyedi, G Hajnoczky… - Experimental Physiology …, 1991 - Wiley Online Library
A Spat, P Enyedi, G Hajnoczky, L Hunyady
Experimental Physiology: Translation and Integration, 1991•Wiley Online LibraryThere are several factors acting on adrenal glomerulosa cells (Miiller, 1988) but only
angiotensin II, corticotropin (ACTH), potassium ionsand (the inhibitory agent) atrial
natriuretic hormone are accepted as physiological factors in the control of aldosterone
secretion. Angiotensin II acts through the formation of two second messengers: inositol 1, 4,
5-trisphosphate (InsP3) and diacylglycerol (DAG). InsP3 evokes the release of Ca2" from an
internal store while DAG induces protein phosphorylation via the activation of protein kinase …
angiotensin II, corticotropin (ACTH), potassium ionsand (the inhibitory agent) atrial
natriuretic hormone are accepted as physiological factors in the control of aldosterone
secretion. Angiotensin II acts through the formation of two second messengers: inositol 1, 4,
5-trisphosphate (InsP3) and diacylglycerol (DAG). InsP3 evokes the release of Ca2" from an
internal store while DAG induces protein phosphorylation via the activation of protein kinase …
There are several factors acting on adrenal glomerulosa cells (Miiller, 1988) but only angiotensin II, corticotropin (ACTH), potassium ionsand (the inhibitory agent) atrial natriuretic hormone are accepted as physiological factors in the control of aldosterone secretion. Angiotensin II acts through the formation of two second messengers: inositol 1, 4, 5-trisphosphate (InsP3) and diacylglycerol (DAG). InsP3 evokes the release of Ca2" from an internal store while DAG induces protein phosphorylation via the activation of protein kinase C (PK-C). Elevated extracellular K+ concentration triggers hormone secretion by enhancing Ca2" influx through the plasma membrane. The action of ACTH is
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