Transcription regulation by distal enhancers: who's in the loop?
R Stadhouders, A van den Heuvel, P Kolovos… - …, 2012 - Taylor & Francis
Transcription, 2012•Taylor & Francis
Genome-wide chromatin profiling efforts have shown that enhancers are often located at
large distances from gene promoters within the noncoding genome. Whereas enhancers
can stimulate transcription initiation by communicating with promoters via chromatin looping
mechanisms, we propose that enhancers may also stimulate transcription elongation by
physical interactions with intronic elements. We review here recent findings derived from the
study of the hematopoietic system.
large distances from gene promoters within the noncoding genome. Whereas enhancers
can stimulate transcription initiation by communicating with promoters via chromatin looping
mechanisms, we propose that enhancers may also stimulate transcription elongation by
physical interactions with intronic elements. We review here recent findings derived from the
study of the hematopoietic system.
Genome-wide chromatin profiling efforts have shown that enhancers are often located at large distances from gene promoters within the noncoding genome. Whereas enhancers can stimulate transcription initiation by communicating with promoters via chromatin looping mechanisms, we propose that enhancers may also stimulate transcription elongation by physical interactions with intronic elements. We review here recent findings derived from the study of the hematopoietic system.
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