Does high MHC class II gene expression in normal lungs account for the strong immunogenicity of lung allografts?

IPJ Alwayn, R Xu, WH Adler, DS Kittur - Transplant international, 1994 - Springer
IPJ Alwayn, R Xu, WH Adler, DS Kittur
Transplant international, 1994Springer
Clinical experience has demonstrated that lung allografts are considerably more
immunogenic than liver allografts although both organs contain equivalent amounts of
lymphoreticular tissue. Northern blot analysis of MHC class II gene expression in various
murine organs with I-AB and I-EB gene-specific oligonucleotide probes revealed that MHC
class II expression in lungs is semiquantitatively higher than in the liver and other organs
with the exception of the spleen. We conclude that this high MHC class II expression strongly …
Abstract
Clinical experience has demonstrated that lung allografts are considerably more immunogenic than liver allografts although both organs contain equivalent amounts of lymphoreticular tissue. Northern blot analysis of MHC class II gene expression in various murine organs with I-AB and I-EB gene-specific oligonucleotide probes revealed that MHC class II expression in lungs is semiquantitatively higher than in the liver and other organs with the exception of the spleen. We conclude that this high MHC class II expression strongly suggests that the lymphoreticular tissue in the lungs is in a state of activation. This may be an important reason for the strong immunogenicity of lung allografts.
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