[HTML][HTML] Tolerance and chimerism after renal and hematopoietic-cell transplantation

JD Scandling, S Busque… - … England Journal of …, 2008 - Mass Medical Soc
JD Scandling, S Busque, S Dejbakhsh-Jones, C Benike, MT Millan, JA Shizuru, RT Hoppe
New England Journal of Medicine, 2008Mass Medical Soc
We describe a recipient of combined kidney and hematopoietic-cell transplants from an HLA-
matched donor. A post-transplantation conditioning regimen of total lymphoid irradiation and
antithymocyte globulin allowed engraftment of the donor's hematopoietic cells. The patient
had persistent mixed chimerism, and the function of the kidney allograft has been normal for
more than 28 months since discontinuation of all immunosuppressive drugs. Adverse events
requiring hospitalization were limited to a 2-day episode of fever with neutropenia. The …
We describe a recipient of combined kidney and hematopoietic-cell transplants from an HLA-matched donor. A post-transplantation conditioning regimen of total lymphoid irradiation and antithymocyte globulin allowed engraftment of the donor's hematopoietic cells. The patient had persistent mixed chimerism, and the function of the kidney allograft has been normal for more than 28 months since discontinuation of all immunosuppressive drugs. Adverse events requiring hospitalization were limited to a 2-day episode of fever with neutropenia. The patient has had neither rejection episodes nor clinical manifestations of graft-versus-host disease.
The New England Journal Of Medicine