Inhibition of inducible nitric oxide synthase prevents graft injury after transplantation of livers from rats after cardiac death
This study investigated the roles of inducible nitric oxide synthase (iNOS) in the failure of rat
liver grafts from cardiac death donors (GCDD). Livers were explanted after 30-minute aorta
clamping and implanted after 4-hour storage in University of Wisconsin solution. The iNOS
expression increased slightly in grafts from non–cardiac death donors (GNCDD) but
markedly in GCDD. Serum nitrite and nitrate and hepatic 3-nitrotyrosine adducts, indicators
of NO and peroxynitrite production, respectively, were substantially higher after …
liver grafts from cardiac death donors (GCDD). Livers were explanted after 30-minute aorta
clamping and implanted after 4-hour storage in University of Wisconsin solution. The iNOS
expression increased slightly in grafts from non–cardiac death donors (GNCDD) but
markedly in GCDD. Serum nitrite and nitrate and hepatic 3-nitrotyrosine adducts, indicators
of NO and peroxynitrite production, respectively, were substantially higher after …