Inhibition of inducible nitric oxide synthase prevents graft injury after transplantation of livers from rats after cardiac death

Y Shi, H Rehman, GL Wright, Z Zhong - Liver Transplantation, 2010 - journals.lww.com
This study investigated the roles of inducible nitric oxide synthase (iNOS) in the failure of rat
liver grafts from cardiac death donors (GCDD). Livers were explanted after 30-minute aorta
clamping and implanted after 4-hour storage in University of Wisconsin solution. The iNOS
expression increased slightly in grafts from non–cardiac death donors (GNCDD) but
markedly in GCDD. Serum nitrite and nitrate and hepatic 3-nitrotyrosine adducts, indicators
of NO and peroxynitrite production, respectively, were substantially higher after …