[HTML][HTML] Donor-specific CD8+ Foxp3+ T cells protect skin allografts and facilitate induction of conventional CD4+ Foxp3+ regulatory T cells

NM Lerret, JL Houlihan, T Kheradmand… - American Journal of …, 2012 - Elsevier
CD4+ regulatory T cells play a critical role in tolerance induction in transplantation. CD8+
suppressor T cells have also been shown to control alloimmune responses in preclinical
and clinical models. However, the exact nature of the CD8+ suppressor T cells, their
induction and mechanism of function in allogeneic transplantation remain elusive. In this
study, we show that functionally suppressive, alloantigen-specific CD8+ Foxp3+ T cells can
be induced and significantly expanded by stimulating naļve CD8+ T cells with donor …