Inhibitory CD8+ T cells in autoimmune disease

M Suzuki, C Konya, JJ Goronzy, CM Weyand - Human immunology, 2008 - Elsevier
Rheumatologists have long been focused on developing novel immunotherapeutic agents
to manage such prototypic autoimmune diseases as rheumatoid arthritis (RA) and systemic
lupus erythematosus (SLE). The ultimate challenge in providing immunosuppressive
treatment for patients with RA and SLE has derived from the dilemma that both protective
and harmful immune responses result from adaptive immune responses, mediated by highly
diverse, antigen-specific T and B cells endowed with powerful effector functions and the …