High expression of ILT3 and ILT4 is a general feature of tolerogenic dendritic cells

JS Manavalan, PC Rossi, G Vlad, F Piazza… - Transplant …, 2003 - Elsevier
The direct interaction between antigen specific CD8+ CD28− T suppressor cells (TS) with
dendritic cells (DC) results in the tolerization of DC by inducing the upregulation of
immunologlobulin like transcript 3 (ILT3) and ILT4. We show here that such tolerogenic DC
anergize alloreactive CD4+ CD45RO+ CD25+ T cells converting them into regulatory T cells
(TR), which in turn, continue the cascade of suppression by tolerizing other DC. Interleukin
10 (IL-10) and interferon-α (IFN-α) also induce ILT3 and ILT4 upregulation in DC, rendering …