Comparison of lung and kidney allografts in induction of tolerance by a mixed-chimerism approach in cynomolgus monkeys
A Aoyama, CY Ng, TM Millington, S Boskovic… - Transplantation …, 2009 - Elsevier
BACKGROUND: We have previously reported the successful induction of renal allograft
tolerance in non-human primates using a nonmyeloablative conditioning regimen to
produce a mixed-chimeric state in the recipient. In the present study, we applied this same
technique to lung allotransplantation in cynomolgus monkeys. METHODS: Nine pairs of fully
major histocompatibility complex (MHC)-mismatched cynomolgus monkeys were used. The
conditioning regimen consisted of total body irradiation, thymic irradiation, and …
tolerance in non-human primates using a nonmyeloablative conditioning regimen to
produce a mixed-chimeric state in the recipient. In the present study, we applied this same
technique to lung allotransplantation in cynomolgus monkeys. METHODS: Nine pairs of fully
major histocompatibility complex (MHC)-mismatched cynomolgus monkeys were used. The
conditioning regimen consisted of total body irradiation, thymic irradiation, and …